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Alpha Glucosyl Hesperidin

sub hesperidin bar


For centuries in Japan, citrus peels have been added to hot bath water both for their relaxing aromatic effects and to provide 'a body warming sensation' after bathing. It is now understood that hesperidin, which belongs to a class of natural substances known as bioflavonoids, is an active component of citrus peel and is responsible for the body warming sensation by stimulating circulation to the skin.
As hesperidin is poorly soluble it is difficult to use in many health, beauty and cosmetic products. α glucosyl hesperidin from Hayashibara (glucosyl hesperidin) is a highly soluble form of hesperidin, making it possible for the first time to utilize the benefits of hesperidin in many cosmetics products.
glucosyl hesperidin molecular
Glucosyl hesperidin is composed of natural glucose and hesperidin, bound together using proprietary technology developed exclusively by Hayashibara. This process results in dramatically improved solubility while retaining all of the natural biologic functions of hesperidin.

Improve Skin Tone

Many skin problems, such as dark circles under the eyes, dull skin, dark skin and puffy skin, can be due to poor circulation to the skin.
Lack of circulation to the skin can be caused by day-to-day stress, a cold climate, lack of exercise or lack of sleep; but the result is always the same: tired, older looking skin.
Glucosyl hesperidin has been scientifically shown to improve circulation when applied to the skin, thus helping to overcome the negative physical effects caused by stress, tiredness and cold.
By stimulating surface circulation, glucosyl hesperidin can improve skin tone and color, helping to combat
  • dark circles under the eyes
  • dull complexion
  • tired skin
  • aging skin
  • puffy skin


Natually in the Skin

The regular application of a cream containing 1% glucosyl hesperidin has been shown to stimulate circulation to the skin. The images below show how glucosyl hesperidin helps to improve circulation to the surface of the skin. In these pictures, the right hand has had applications of a cream containing 1% glucosyl hesperidin for a period of one month. The left hand is untreated, for control purposes.
Figure 1 shows skin surface temperature under normal conditions.
Figures 2 to 4 show the relative recovery in skin temperature 10 and 20 minutes after removal from cold water, both hands having been plunged into cold water for one minute.
glucosyl hesperidin 1%
Cream with (right hand) or without (left hand) 1% glucosyl hesperidin was applied to each hand twice a day (morning and night) for a month. Hands were put in cold water (10℃) for 1 minute to reduce skin temperature. Hands were then kept at room temperature and the skin surface temperature was measured every 5 minutes using thermography.


Increase Skin Temperature


glucosyl hesperidin vs. temperature
For centuries in Japan, citrus peels have been used in therapeutic bathing to help alleviate problems commonly associated with poor circulation, such as constantly cold hands and feet and certain types of muscular aches. Due to its high solubility, glucosyl hesperidin may be used in aromatherapy bathing products to help stimulate circulation to the skin and provide a continuing soothing warmth after bathing.
This activity has been demonstrated using human volunteers. When added to bath water (0.01% w/v) glucosyl hesperidin resulted in increased skin temperature.